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We believe Intense Pulsed Light (IPL) is great, but it isn't effective enough. Following years of research, Espansione Group has developed an innovative photobiomodulation technology, Light Modulation® LLLT for the treatment of the ocular surface (anterior segment) and beyond onto the retina with dry AMD applications (currently under LightWave II clinical trial).

Introducing Light Modulation® Low-level Light Therapy—a radically different technology and approach. By pairing it with Optimal Power Energy® IPL, Espansione Group’s very own, enhanced IPL technology, Espansione Group was able to resolve common IPL limitations, setting a new standard in ocular surface treatment.

“Combined OPE® IPL and LM® LLLT therapies in a single treatment produced significant improvements in tear breakup time and MGD grading scores, with an associated improvement in the patient’s subjective OSDI score.”

STONECIPHER, KARL, ET AL. COMBINED LOW LEVEL LIGHT THERAPY AND INTENSE PULSED LIGHT THERAPY FOR THE TREATMENT OF MEIBOMIAN GLAND DYSFUNCTION. CLINICAL OPHTHALMOLOGY (AUCKLAND, NZ), 2019, 13: 993.

Onto the Retina

We’re pioneering what’s next in retinal care, starting with dry AMD management through two large-scale global multi-centric research studies.

Learn more on our research efforts to prevent and manage dry AMD, LightWave I and LightWave II, and dive deeper on Light Modulation® LLLT.

Bibliography

Throughout the years, valued members of the scientific community have contributed to the resonance of Espansione technologies such as Light Modulation® LLLT and Optimal Power Energy® IPL by publishing a vast array of research and scientific, peer-reviewed papers.

—Ocular surface
—Retina
Ocular surface
DRY EYE DISEASE, MGD, CLIDE/CLD
31+
Papers + articles
CHALAZION & STYE
5+
Papers + articles
Sjögren's syndrome
2+
Papers + articles
Blepharitis & demodex
3+
Papers + articles
Refractive surgery
4+
Wip clinical trials
Retina
Dry amd
2+
Wip clinical trials
—Latest publications
  1. D’SOUZA, Sharon, et al. Clinical and Molecular Outcomes After Combined Intense Pulsed Light Therapy With Low-Level Light Therapy in Recalcitrant Evaporative Dry Eye Disease With Meibomian Gland Dysfunction. Cornea, 2021.
  2. GIANNACCARE, Giuseppe, et al. Low-Level Light Therapy Versus Intense Pulsed Light for the Treatment of Meibomian Gland Dysfunction: Preliminary Results From a Prospective Randomized Comparative Study. Cornea, 2022.
  3. SOLOMOS, Leonidas, et al. Meibomian Gland Dysfunction: Intense Pulsed Light Therapy in Combination with Low-Level Light Therapy as Rescue Treatment. Medicina, 2021, 57.6: 619.
  4. STONECIPHER, Karl; POTVIN, Richard. Low level light therapy for the treatment of recalcitrant chalazia: a sample case summary. Clinical Ophthalmology (Auckland, NZ), 2019, 13: 1727.
  5. STONECIPHER, Karl, et al. Combined low level light therapy and intense pulsed light therapy for the treatment of meibomian gland dysfunction. Clinical Ophthalmology (Auckland, NZ), 2019, 13: 993.
  6. DI MARINO, Matteo, et al. Combined Low-Level Light Therapy and Intense Pulsed Light Therapy for the Treatment of Dry Eye in Patients with Sjögren’s Syndrome. Journal of ophthalmology, 2021, 2021.
  7. MARTA, Ana, et al. Intense Pulsed Plus Low-Level Light Therapy in Meibomian Gland Dysfunction. Clinical Ophthalmology (Auckland, NZ), 2021, 15: 2803.
  8. PÉREZ-SILGUERO, Miguel Angel, et al. Combined Intense Pulsed Light and Low-Level Light Therapy for the Treatment of Dry Eye: A Retrospective Before–After Study with One-Year Follow-Up. Clinical Ophthalmology (Auckland, NZ), 2021, 15: 2133.

Medical Affairs

To have a practitioner-to-practitioner conversation, learn about the forefront of scientific research, or make sure you provide the best care to your patients, get in touch with our Medical Affairs team.

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