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Light Science
Various frequencies.
Endless possibilities.
Various frequencies.
Endless possibilities.
LM® LLLT is our patented photobiomodulation technology—it works by triggering endogenous heating, stimulating ATP production in both ophthalmological and dermatological applications.
This innovative approach ensures effective and versatile outcomes, whether addressing anterior and posterior segment conditions in ophthalmology or catering to broader applications in dermatology.
Light Modulation® Low-level Light Therapy can be leveraged employing different light frequencies—each with its own unique benefits and use cases.
—ANTERIOR SEGMENT USE CASES
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Red Light
LM® LLLT red light plays an important role, addressing various conditions of Anterior Segment such as DED/ MGD, Chalazion, Sjogren’s Syndrome, Stye, Blepharitis, Ocular Surgery with notable effectiveness.
Key Facts for Ophthalmology:
- ① Improves cellular metabolism by increasing ATP production within mitochondria
- ② Reduces inflammation by regulating antioxidant defenses and mitigating oxidative stress.
- ③ Light-induced activation of transcription factors and signaling pathways.
Used for Inflammation Reduction and ATP Production Stimulus.
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Blue Light
LM®LLLT blue light serves a crucial role in anterior segment management, particularly in addressing conditions such as Demodex, Blepharitis and Rosacea.
Key Facts for Ophthalmology:
- ① Blue light energy is absorbed by porphyrins within bacteria, initiating photosensitization
- ② Exposure to the light results in photodynamic inactivation, effectively killing bacteria.
- ③ Membrane-bound porphyrin molecules generate singlet oxygen radicals, causing damage to the cell wall of gram-positive bacteria and leading to cell death.
- ④ The relatively weak defense mechanism in bacteria against singlet oxygen contributes to the high efficiency of photodynamic inactivation.
Used for Bacteria Elimination, Microbiome Stabilization
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Yellow Light
LM® LLLT yellow light proves to be a valuable asset in anterior segment management, offering targeted benefits for specific post-invasive procedures (e.g., Post - Blepharoplasty)
Key Facts for Ophthalmology:
- ① Yellow light acts on mitochondrial respiration, increasing ATP production.
- ② Promotes the release of nitric oxide, aiding in neuro-transmission and tissue repair.
- ③ Decreases the inflammatory response, reducing edema.
- ④ Increases skin elasticity and decreases metalloproteinases activity.
Used for Drainage and Swelling Reduction
—POSTERIOR SEGMENT USE CASES
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Yellow Light
The Yellow light (590 nm wavelength) naturally inhibits expression of vascular endothelial growth factor (VEGF), a signaling protein that stimulates the formation of blood vessels that contributes to the development of the wet-form of AMD.
It also increases the signaling protein, nitric oxide which reduces oxidative stress-mediated injury in the cell and increases local O2 delivery. Light absorption leads to NO dissociation from CCO, restoring mitochondrial function and increasing ATP production.
> Oxydative Stress Reduction
> VEGF Inhibition
> Oedema Reduction & Drainage
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Red Light
The Red (630 nm) light exposure is directly associated with a significant increase in ATP. The 630 nm wavelength is chosen based on its known interaction with cellular photo acceptors in CCO.
The 630 nm wavelength promote electron transfer and oxygen binding, respectively, in CCO leading to restoration of mitochondria function and increases in metabolic activity (i.e. energy production) and inhibition in inflammatory events and cells death.
> HIF-1α-Factor Stimulus
> Inflammatory Biomarkers Reduction
> ATP Stimulus
—DERMATOLOGY & TRICHOLOGY USE CASES
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Red Light
In dermatology, LM® LLLT red light is a powerhouse for inflammation reduction and ATP production stimulus, boasting remarkable efficacy in stimulating cell activity and tissue regeneration, benefiting both skin and hair conditions.
Key Facts for Dermatology:
- ① The red light penetrates the tissue down to the dermis, directly affecting ATP production.
- ② Photochemical effects stimulate cell activity and the proliferation of fibroblasts and keratinocytes.
- ③ Results include an increase in tissue tonicity, yielding firmer and brighter skin with enhanced hydration and oxygenation.
- ④ LM® LLLT red light is effective in all treatments promoting skin renewal.
Key Facts in Trichology:
- ① Red light reactivates scalp vascularization, crucial for nourishing hair.
- ② Decreases tissue stiffening around follicles, counteracting micro-irritations.
- ③ Facilitates nutrient distribution, including vitamins, minerals, amino acids, and proteins in the scalp.
- ④ Activates Cytochrome C Oxidase, promoting stem cell differentiation and transitioning hair follicles to the growth phase.
•
Blue Light
In dermatology, LM® LLLT blue light targets blocked sebaceous follicles, addressing redness, inflammation, and comedones associated with acne.
Key Facts for Dermatology:
- ① Through the blue light, the system delivers an absorption peak for porphyrins present in the bacteria.
- ② This process initiates a series of chain reactions, generating highly reactive Singlet Oxygen (O2), selectively destroying the bacterium’s RNA sequence without harming surrounding cells.
•
Yellow Light
In dermatology, LM® LLLT yellow light extends its capabilities, providing a holistic approach to drainage and swelling reduction.
Key Facts for Dermatology:
- ① Yellow light acts on mitochondrial respiration and increases ATP production.
- ② Promotes the release of nitric oxide, aiding in neuro-transmission and tissue repair.
- ③ Decreases the inflammatory response by reducing erythema.
- ④ Increases skin elasticity and decreases metalloproteinases activity.
- ⑤ Acts on the lymphatic system, stimulating cell metabolism and promoting a detoxifying action to relieve swelling conditions.
- ⑥ Produces a reduction of edema in various formations.
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Infrared Light *
In dermatology, the distinctive advantages of infrared light are in the spotlight.
Key Facts for Dermatology:
- ① Stimulates vasodilation for increased blood flow in the treated area.
- ② Enhances the delivery of oxygen, nutrients, and essential molecules to cells, promoting tissue repair and regeneration.
- ③ Activates cellular mechanisms responsible for tissue repair and regeneration, particularly effective in cases of deep cutaneous aging.
- ④ Aids in the reduction of scar tissue formation by promoting remodeling of collagen fibers within scars, leading to improved scar appearance and flexibility.
* Available only for Dermatological Use
Scientific Coverage
Impact on tear breakup time
Impact on ocular surface disease index (i.e., OSDI)
STONECIPHER, Karl, et al. Combined low level light therapy and intense pulsed light therapy for the treatment of meibomian gland dysfunction. Clinical Ophthalmology, 2019
Benefits
Studies show that tear production quality increases dramatically, as the treatment nearly doubles tear breakup time, resulting in immediate relief of symptoms.
And consequently, the treatment improved by 10 points or more the patient’s ocular surface disease index—i.e., OSDI Index, in over 70% of cases, with only one treatment.
Endogenous Heating
Recently run thermography studies have shown upper and lower meibomian glands being simultaneously, directly treated at optimal temperature—i.e., 42°C, through LM® LLLT.
Light Modulation® LLLT triggers endogenous heating to both eyelids, stimulating ATP production and removing blockage from meibomian glands preventing proper functioning—and it does so with zero discomfort for the patient.
Courtesy of Dr. Heiko Pult—OD, PHD